Pharma-Seed #5 – Omega-3s

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FOUND IN: Tilapia, salmon, tuna and other cold-water fish; flaxseed, hemp oil, chia seeds, walnuts

Common names: Omega-3 fatty acids, Fish Oils

Drug Name: Eicosapentaenoic acid (EPA), Docosahexaenoic Acid (DHA), and Alpha-Linolenic (ALA))

Fish, such as tilapia, which are used in Green Relief’s aquaponic systems, contain essential omega-3 fatty acids that are vital for cardiovascular and mental health. Thanks to Green Relief’s sustainable growing methods, we are able to feature the medical benefits of omega-3, the full life cycle of tilapia, and how the fish contribute to cannabis cultivation and feeding our communities.


Medicinal Uses

Usual Dosing: It is recommended to consume at least 2 fatty fish meals per week. If that is not feasible, then supplement with 2000mg/day to support cardiovascular and mental health. For lipid lowering effects, a dosage of 4000mg/day may be required [1].

  • Cardiovascular health
  • Anti-inflammatory
  • Dry eye
  • Central nervous system functionality
  • Mood disorders
  • Memory

Common Side Effects:

Gastrointestinal - Diarrhea
Gastrointestinal - Burping
Gastrointestinal - Acid Reflux
Gastrointestinal - Nausea
Prolonged bleeding time
    warning sign

    Potential Drug interactions

    • Warning symbol
    • Potential Drug interactions

    Can potentiate the bleeding effects of Coumadin, Plavix and other blood-thinning agents. Use with caution if you are taking blood thinners, or speak with your Hybrid Pharm pharmacist.

Omega-3 fish oil in bottle

How it works

Omega 3 fatty acids are essential nutrients for our growth, development and proper cellular function.

They are essential because our bodies cannot produce it, so we must source it from our diet or supplements. All of our cells in our body are made up of lipophilic aka (fat-loving) molecules. The central nervous system, specifically, is enriched with polyunsaturated fatty acids that form the structures of cell membranes [2]. When we ingest fish, take supplements or eat plant-based foods rich in omegas, we are providing our bodies with the building blocks needed to maintain proper neuronal function.

Omega-3 pill in fish shape

How it relates to cannabis

The endocannabinoid system (ECS) is made up of receptors (CB1, CB2), ligands (molecules that bind to the receptors) and enzymes that break down the ligands. The ligands are known as anandamide (AEA) and 2-arachidonoylglycerol (2-AG), which are derived from long-chain polyunsaturated fatty acids such as arachidonic acid and DHA, an omega-3 fatty acid [3]. This means that when we take omega-3s, we are increasing our endocannabinoid tone via increasing the precursors to AEA and 2-AG, our endogenous cannabinoids.

Since omega-3 fatty acids contain these building blocks for our ECS, a deficiency can impair proper functionality. This can lead to mental health disorders such as depression [4], anxiety, attention deficit hyperactivity disorder (ADHD), and increased cardiovascular risks. Therefore, without omega-3 fatty acids in our bodies, we would not be able to synthesize endocannabinoids leading to an imbalance in our central and peripheral nervous systems.

The short of it: Omega-3 fatty acids feed the endocannabinoid system.

Endocanabanoid system CB1 CB2

Endocanabanoid system CB1 CB2

Tilapia Use in Cannabis Cultivation

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Commitment To Sustainability

At Green Relief, Canada’s leading licensed producer of medical cannabis using aquaponics as a growing method, our mission is simple. We help patients improve their quality of life while also being environmentally responsible, and giving back to the community.


Aquaponics is a form of agriculture that combines aquaculture (raising fish), with hydroponics (growing plants in water). At Green Relief, we integrate the two practices to create a balanced, closed-loop ecosystem that is constantly recirculating.

Green Relief Aquapoics how it works

Owing to this innovative system, Green Relief uses less water than conventional agriculture, and fewer fertilizers and pesticides. In fact, because we grow by way of aquaponics, we can’t add any harmful substances to our production practices. Doing so would not only put our fish at risk, but it would also be detrimental to the integrity of our system. Healthy fish mean healthy plants!

How it works

In aquaponics, the following three key players must be present at all times to ensure the system flourishes:

  • Fish that produce waste;
  • Beneficial bacteria in the system to convert waste into plant nutrients;
  • And plants that take up the nutrients to grow, while also filtering the water so it can return to the fish tanks and the cycle can repeat itself.
  • View the Green Relief Medical Cannabis Facility Tour

    Learn why Green Relief uses Tilapia

    Social Responsibility

    In addition to reducing our environmental footprint, Green Relief’s aquaponic systems also allow us to give back to the community.

    Unlike other aquaponic companies that harvest both their plants and fish as cash crops, Green Relief chooses to donate our fish once they’ve reached market size instead.

    All of Green Relief’s fish are tilapia, which are fed Canadian-made, certified-organic feed. We chose tilapia because the fish grow quickly, and are able to thrive under the temperature and pH conditions in which we maintain our aquaponic systems for ideal plant growth. They also provide a healthy protein source.

    To date, Green Relief has donated more than 40,000 tilapia fish to Second Harvest, a food rescue service that delivers surplus meals to people in need. This partnership has allowed us to provide up to 54 daily meals to the local community.

    Energy Conservation

    At Green Relief, we use energy-saving LED lights in our grow rooms to curb our energy consumption.

    Plus, our earth-sheltered facility is equipped with a green roof to provide the highest insulation value, as well as natural protection from the elements.

    Additionally, the installation of a sophisticated HVAC system in our facility ensures we consume less energy throughout our daily operations.

    Green Planet

    Cannabis Strain Review Icon

    Strain Review

    LOW TIDE from Green Relief

    HYBRID – Indica-dominant hybrid
    1:2 THC to CBD ratio
    Flower: 8% THC – 14% CBD
    Oil: 8mg/ml THC – 14mg/ml CBD
    Oil available in: 30ml and 60ml bottles
    Dry flower available 5, 10, and 30-gram packages

    Low Tide’s origins are a cross between old Skunk and Afghani lineages, and its genetic profile comprises most of the cannabis genome. Low Tide has dense, conical flowers with herbal, fruity aromas and an earthy, citrus taste.

    With its mellow effects, Low Tide calms the mind and relaxes the body, making it a great daytime option and good fit for those who are newer to medical cannabis. Many of our patients report that Low Tide allows them to focus and get on with their daily activities. Novice cannabis users report it to be a gentle and effective sleep aid.

    This strain is great for:

    • Pain/Inflammation
    • Insomnia
    • Depression/Anxiety
    • Parkinson’s disease
    • Multiple Sclerosis
    • Epilepsy
    Learn more about this strain
    Green Relief Low Tide StrainAngelo Muscari approved cartoon

    * Staff preferred - selected by Angelo

    Terpene Profile:

    0.91% total terpenes

    Beta-Mycrene - 0.404
    Trans-Caryophyllene - 0.122
    Limonene - 0.091
    Guaiol - 0.061
    Alpha-Humulene - 0.052
    Alpha-Bisabolol - 0.037
    Alpha-Terpineol - 0.028
    Alpha-Pinene - 0.025
    Linalool - 0.023
    Fenchyl Alcohol - 0.022

    Cannabis Strain Review Icon

    Strain Review

    DEEP PURPLE from Green Relief

    Flower: 12% THC – <1% CBD
    Oil: 27.5mg/ml THC – 0mg/ml CBD
    Oil available in: 30ml and 60ml bottles
    Dry flower available 5, 10, and 30-gram packages

    A rare sativa that originates from the volcanic soils of Hawaii, Deep Purple lives up to its name with dazzling purple buds.

    Deep Purple’s effects include focus and clarity of mind that allows the body to take on the day’s events. Patients can expect to feel uplifted and encouraged, making Deep Purple a popular daytime option.

    This strain is great for:

    • Depression
    • Anxiety
    • Appetite loss
    • Gastrointestinal disorders
    • PTSD
    • Fatigue
    Learn more about this strain
    Green Relief Low Tide Strain

    Terpene Profile:

    0.78% total terpenes

    Guaiol - 0.065
    Beta-Mycrene - 0.137
    Trans-Caryophyllene - 0.102
    Trans-Nerolidol - 0.097
    Alpha-Pinene - 0.063
    Terpinolene - 0.050
    Beta-Pinene - 0.042
    Limonene - 0.034
    Linalool - 0.012
    Boreol Isomers - 0.009

    Cannabis Strain Review Icon

    Strain Review

    CARIBBEAN CRUSH from Green Relief

    1:2 THC to CBD ratio
    Flower: 18% THC – <1%CBD
    Dry flower available 5, 10, and 30-gram packages

    A potent strain that packs a punch, Caribbean Crush has a moss-like appearance, and a pungent aroma with earthy flavours and hints of citrus. With a very strong and calming effect on the nerves, Caribbean Crush immediately lifts the spirits with effects of euphoria and full-body relaxation.

    Caribbean Crush isn't recommended for first-timers as even regular medical cannabis users have experienced tiredness after using it. This, however, makes it a great nighttime option for those with trouble sleeping.

    This strain is great for:

    • Insomnia
    • Anxiety
    • Depression
    • Hyperactivity
    • Migraines/Headaches
    • Pain
    Learn more about this strain
    Green Relief Low Tide Strain

    Terpene Profile:

    1.16% total terpenes

    Beta-Mycrene - 0.507
    Trans-Caryophyllene - 0.184
    Limonene - 0.157
    Guaiol - 0.090
    Alpha-Humulene - 0.060
    Fenchyl Alchohol - 0.036
    Alpha-Terpineol - 0.029
    Alpha-Pinene - 0.026
    Boreol Isomers - 0.014

    Uses in cooking and holistic wellness

    Cranberry Orange Muffin Recipe

    Fragrant Seared Tilapia with Citrus Salad Topper

    Makes: 12   |   Serves: 4   |   Prep Time: 15 minutes   |   Cook Time: 15 minutes

    Fish is an amazing way to source the omega-3s we need for our body’s health. Tilapia is rich in minerals, vitamins and nutrients, and is a significant source of protein and omega-3 fatty acids. This meal would be great as a brain-boosting lunch before a meeting or presentation thanks to the high potassium and omega-3 content found in the fish; both known to increase neurological function [5].

    • 4 Tilapia fillets
    • ½ cup of Avocado Oil
    • 1 bunch of fresh basil
    • 2 Medium size tangerines or oranges
    • 1 lemon
    • 4 Roma tomatoes diced
    • ½ cup of zucchini thinly sliced
    • 1 tsp maple syrup
    • 2 tbsp minced red onion
    • 1 ½ tsp minced garlic
    • Salt and Pepper
    • Pinch of red pepper flakes (optional)


    • STEP 1

      Optional: Infuse ½ cup of avocado oil with 5g of chopped basil using the LEVO, about 15-30 minutes at 200° Fahrenheit [6]

    • STEP 2

      Chop ¼ cup of basil, peel and dice both oranges- ensuring all of the white skin in removed only leaving the segments (keep the peels for later), dice tomatoes, red onion and slice the zucchini using a mandolin or peeler, mince the garlic.

    • STEP 3

      Cut lemon in half, keep half for juice and slice other half into rounds.


    • STEP 1

      Preheat oven to 350° Fahrenheit

    • STEP 2

      Combine 1 tbsp of avocado oil, oranges, tomatoes, basil, zucchini, onion, maple syrup, ½ tsp minced garlic, fresh sea salt and cracked black pepper and crushed red pepper flakes in a bowl. Mix together and let sit for the duration of the tilapia preparation (add in any juice from the oranges that is left).

    • STEP 3

      Heat a generous drizzle of infused or regular avocado oil in a frying pan on medium high heat. Place a few slices of lemon and remaining minced garlic in the pan while it warms up. Add tilapia to the hot pan and sear on medium high heat for about 3-5 minutes or until it begins to gently brown. Flip fillets and repeat on other side, about 3 minutes (those closer to the centre of the pan will cook quicker).

    • STEP 4

      Squeeze some lemon juice from leftover half of the lemon on fillets and place the pan in the oven for about 3-5 minutes or until the fish are flakey and white in the centre.

    • STEP 5

      Remove from oven, plate and lightly zest orange peel on the fish. Top fillets with the fresh citrus basil salad and serve along your favourite side dishes.

    1. (2019). Login. [online] Available at: [Accessed 5 Feb. 2019].
    2. (2019). Office of Dietary Supplements - Omega-3 Fatty Acids. [online] Available at: [Accessed 1 Feb. 2019].
    3. Lafourcade, M., Larrieu, T., Mato, S., Duffaud, A., Sepers, M., Matias, I., De Smedt-Peyrusse, V., Labrousse, V., Bretillon, L., Matute, C., Rodríguez-Puertas, R., Layé, S. and Manzoni, O. (2011). Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions. Nature Neuroscience, 14(3), pp.345-350.
    4. The Nutrition Source. (2019). Omega-3 Fatty Acids: An Essential Contribution. [online] Available at: [Accessed 23 Jan. 2019].
    5. Oscar D Rangel-Huerta and Angel Gil, Effect of omega-3 fatty acids on cognition: an updated systematic review of randomized clinical trials, Nutrition Reviews, 76, 1, (1), (2018).
    6. Levo Calculator Link:

    Strain review by Hybrid's own Angelo Muscari

    Mordern day uses, How it works and how it relates to cannabis sections by Hybrid’s own Rahim Dhalla

    Uses in cooking and holistic wellness and recipe provided by The Healthy Wine Girl - Sarah Kincaid Kelly

    About The Author
    Green Relief Logo
    Green Relief

    Based in Hamilton, Ontario, Green Relief is Canada’s leading licensed producer of medical cannabis using aquaponics to sustainably grow its plants. Green Relief’s mission is simple: supporting the health, and quality of life, of our patients, while advancing the science behind medical cannabis through research that raises the profile of its benefits.
    Learn more about Green Relief

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